Organotin toxicity

Organotin compounds are a class of organic compounds that contain tin atoms bonded to carbon atoms. These compounds have been widely used as fungicides, fungicides, catalysts, etc. in the past. However, they are considered persistent, bioaccumulative and toxic substances that may be toxic to aquatic organisms and may act as immunotoxins. As a result, major markets around the world have legislated to restrict the use of organotins in finished products. For example, EU REACH Annex XVII Article 20 limits the tin content of dibutyltin (DBT), dioctyltin (DOT) and trisubstituted organotin compounds to 0.1% by weight1.

The main damage of organotin compounds to the human body is: the central nervous system will cause Cerebral white matter edema, impairment of oxidative phosphorylation process in cell energy utilization, inhibition of thymus and lymphatic system, impairment of cellular immunity, inhibition of hormone secretion causing diabetes and hyperlipidemia, etc.